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4 drinks you should never have with common antihistamine
Home>Health
Published 12:12 7 May 2026 GMT+1

4 drinks you should never have with common antihistamine

You could be setting yourself up for failure the second that breakfast rolls around

Ella Scott

Ella Scott

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Your favourite go-to beverages could seriously be impacting how well your antihistamine tablets work, experts have warned.

Antihistamines, such as fexofenadine, are used to relieve symptoms associated with allergic rhinitis, commonly referred to as hay fever, as well as calm skin hives (chronic idiopathic urticaria), and take the itch out of insect bites.

Most adults and children can safely consume fexofenadine tablets; however, people who have had problems with their liver, kidneys or heart should inform their doctor or pharmacist before they start using it.

Pregnant people, those who are breastfeeding and those who have ever had an allergic reaction to the antihistamine or any other medicine should also be cautious, as per the NHS.

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But what you wash fexofenadine with may be causing your medication to falter - and it’s not good news for fruit juice-lovers.

Drinks to avoid with fexofenadine

Orange juice

You may want to put your daily glass of orange juice back in the fridge (Getty Stock Image)
You may want to put your daily glass of orange juice back in the fridge (Getty Stock Image)

If you’re someone who loves waking up in the morning to a freshly-squeezed glass of orange juice, then we have bad news for you.

Unfortunately, orange juice can significantly reduce the absorption of fexofenadine, as per experts at Bolt Pharmacy.

This is because compounds in the beverage can inhibit drug transport proteins in the gut wall, potentially reducing its therapeutic effect.

Studies suggest that consuming orange juice alongside the medication can reduce its bioavailability by around a third, or more.

Grapefruit juice

Grapefruit juice and certain cemedications are not a match made in heaven (Getty Stock Image)
Grapefruit juice and certain cemedications are not a match made in heaven (Getty Stock Image)

Much like its citrus sister, grapefruit juice can cause less fexofenadine to enter the blood, decreasing how well the drug works, said Shiew Mei Huang of the US Food and Drug Administration.

Consuming pomelos, a Southeast Asian fruit similar in taste to sweet grapefruits, and tangelos, a tart, tasty citrus fruit hybrid, may also cause issues with fexofenadine absorption, the FDA stated.

Apple juice

Avoid drinking apple juice when taking fexofenadine (Getty Stock Image)
Avoid drinking apple juice when taking fexofenadine (Getty Stock Image)

Another kicker - swigging a sweet glass of apple juice after popping an antihistamine could be why your runny nose and your itchy eyes haven’t been relieved.

Like orange and grapefruit juice, apple can interfere with fexofenadine’s effectiveness.

The beverage can also impact other medications, such as blood pressure drugs and the beta-blocker atenolol, medical anthropologist Terry Graedon told The People’s Pharmacy.

Alcohol

Beer may be the reason why your nose is runny despite taking an antihistamine tablet (Getty Stock Image)
Beer may be the reason why your nose is runny despite taking an antihistamine tablet (Getty Stock Image)

You may be tempted this summer to slam an antihistamine back on your way to the beer garden to make sure your pesky allergies don’t get in the way of a good time.

But be warned: alcohol should not be drunk alongside fexofenadine, as per the NHS.

The health service stated that it’s best not to drink booze alongside the tables because it can make you feel sleepy and may increase side effects such as dizziness.

Drugs.com suggests refraining from the bottle and taking your medication with water instead. This should make it easier for your body to absorb the medication.

Featured Image Credit: IAN HOOTON/SCIENCE PHOTO LIBRARY/Getty Images

Topics: Health, Diet, Drinks, Alcohol

Ella Scott
Ella Scott

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